Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPER1 | Q99527 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 6/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26633120 | 0.81 | PDE3B (0.40) | GPER1PDE2APDE3BPDE3ALRRK2 | |
| SCHEMBL24196343 | 0.81 | FFAR2 (0.40) | GPER1PDE3BPDE3ALRRK2PRKDC | |
| SCHEMBL30403514 | 0.81 | PDE3B (0.40) | GPER1PDE2APDE3BPDE3ALRRK2 | |
| SCHEMBL24196345 | 0.81 | FFAR2 (0.40) | GPER1PDE3BPDE3ALRRK2PRKDC | |
| SCHEMBL29049683 | 0.81 | DRD3 (0.44) | GPER1PDE3BPDE3APIM3PIM2 | |
| SCHEMBL29049699 | 0.78 | GLRA1 (0.42) | GPER1PDE3BPDE3ALRRK2PRKDC | |
| SCHEMBL26633127 | 0.78 | GLRA1 (0.42) | GPER1PDE3BPDE3ALRRK2PRKDC | |
| SCHEMBL26633138 | 0.76 | GPER1 (0.38) | GPER1PDE3BPDE3APIM3PIM2 | |
| SCHEMBL26633115 | 0.76 | GPER1 (0.38) | GPER1PDE3BPDE3APIM3PIM2 | |
| SCHEMBL32933182 | 0.75 | ATM (0.33) | PDE3BPDE3APRKDCATMPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116171276-A | 3- ((1H-pyrazol-4-yl) methyl) -6'- (phenyl) -2H- [1,2' -bipyridin ] -2-one derivatives and related compounds as GRP139 antagonists in methods of treating E.G. depression | 武田药品工业株式会社 | 2023-05-26 | — | — | CN | disclosed |