Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11447916 | 0.81 | MKNK1 (0.50) | THRBKDM4EALDH1A1MAPTL3MBTL1 | |
| SCHEMBL23502018 | 0.76 | CA12 (0.39) | TNKS2PDE3BPDE3AUSP1 | |
| SCHEMBL28431442 | 0.75 | PDE3B (0.47) | SYKTHRBKDM4EALDH1A1MAPT | |
| SCHEMBL15723877 | 0.73 | COMT (0.46) | SYKTNKS2ALDH1A1MAPTMEN1 | |
| SCHEMBL14555509 | 0.73 | PTGS2 (0.45) | KDM4EALDH1A1MAPTPTPRCCTSL | |
| SCHEMBL13575374 | 0.72 | ALDH1A1 (0.41) | THRBKDM4EALDH1A1MAPTL3MBTL1 | |
| SCHEMBL15723950 | 0.72 | PTGS1 (0.44) | ALDH1A1MAPTKCNA5KCNH2PTPRC | |
| SCHEMBL18074847 | 0.72 | PTGS2 (0.52) | THRBALDH1A1MAPTMAP4K4KCNA5 | |
| SCHEMBL9963326 | 0.71 | GCGR (0.42) | — | |
| SCHEMBL18853955 | 0.71 | TDP1 (0.41) | TNKS2KDM4EALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111433195-B | Pyridone derivatives and their use as selective ALK-2 inhibitors | 诺华股份有限公司 | 2023-04-25 | — | — | CN | disclosed |