Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.56 |
| ▸ | ALDH3A1 | P30838 | 4/20 | 0.56 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.56 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 3/20 | 0.55 |
| ▸ | CES1 | P23141 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | RCE1 | Q9Y256 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22655288 | 1.00 | ALDH1A1 (0.56) | ALDH1A1ALDH3A1ALDH2CUL4AACHE | |
| SCHEMBL21001752 | 0.86 | ALDH1A1 (0.65) | ALDH1A1ALDH3A1ALDH2CUL4AACHE | |
| SCHEMBL22667293 | 0.85 | ALDH1A1 (0.60) | ALDH1A1ALDH3A1ALDH2CUL4AACHE | |
| SCHEMBL30404094 | 0.85 | ALDH1A1 (0.60) | ALDH1A1ALDH3A1ALDH2CUL4AACHE | |
| SCHEMBL28606638 | 0.81 | CES1 (0.65) | ALDH1A1ALDH3A1ALDH2CUL4AACHE | |
| SCHEMBL22667351 | 0.80 | ALDH1A1 (0.58) | ALDH1A1ALDH3A1ALDH2CUL4AACHE | |
| SCHEMBL30404925 | 0.80 | ALDH1A1 (0.58) | ALDH1A1ALDH3A1ALDH2CUL4AACHE | |
| SCHEMBL30403461 | 0.79 | CUL4A (0.68) | ALDH1A1ALDH3A1ALDH2CUL4AACHE | |
| SCHEMBL22667286 | 0.79 | CUL4A (0.68) | ALDH1A1ALDH3A1ALDH2CUL4AACHE | |
| SCHEMBL29220077 | 0.78 | ALDH1A1 (0.67) | ALDH1A1ALDH3A1ALDH2CUL4AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111433195-B | Pyridone derivatives and their use as selective ALK-2 inhibitors | 诺华股份有限公司 | 2023-04-25 | — | — | CN | disclosed |