Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 12/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.40 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.40 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.40 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.39 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | STK16 | O75716 | 1/20 | 0.39 |
| ▸ | STK10 | O94804 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23157818 | 0.86 | MTOR (0.57) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| Trifluoroacetic Acid SCHEMBL20553346 | 0.79 | MTOR (0.50) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| Trifluoroacetic Acid SCHEMBL29669743 | 0.79 | MTOR (0.50) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL19299699 | 0.75 | PIK3CD (0.62) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL23150477 | 0.73 | MTOR (0.54) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL19294557 | 0.72 | MTOR (0.71) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL30405300 | 0.71 | PIK3CD (0.56) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL24535571 | 0.69 | MTOR (0.65) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL30353302 | 0.69 | MTOR (0.54) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL20553311 | 0.69 | PIK3CA (0.54) | MTORPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168002-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |