Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.36 |
| ▸ | AGPAT2 | O15120 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25261605 | 1.00 | PLA2G7 (0.45) | PLA2G7S1PR1CYP3A4ABL1ALDH1A1 | |
| SCHEMBL31312426 | 0.89 | PLA2G7 (0.51) | PLA2G7S1PR1CYP3A4ABL1ALDH1A1 | |
| SCHEMBL17595012 | 0.89 | PLA2G7 (0.51) | PLA2G7S1PR1CYP3A4ABL1ALDH1A1 | |
| SCHEMBL16094239 | 0.89 | ALDH1A1 (0.43) | PLA2G7CYP3A4ABL1ALDH1A1CASP1 | |
| SCHEMBL25698931 | 0.84 | CYP3A4 (0.39) | PLA2G7S1PR1CYP3A4ALDH1A1ADORA2A | |
| SCHEMBL25593205 | 0.84 | MAP4K4 (0.42) | S1PR1CYP3A4ALDH1A1ADORA2AADORA1 | |
| SCHEMBL31636298 | 0.84 | PLA2G7 (0.47) | PLA2G7S1PR1CYP3A4ALDH1A1CASP1 | |
| SCHEMBL25699188 | 0.84 | PLA2G7 (0.47) | PLA2G7S1PR1CYP3A4ALDH1A1CASP1 | |
| SCHEMBL25593143 | 0.78 | ABL1 (0.39) | S1PR1ABL1ADORA2AADORA1ADORA3 | |
| SCHEMBL25593067 | 0.78 | S1PR1 (0.37) | S1PR1ABL1ADORA2AADORA1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119604491-A | RAF kinase inhibitors and methods of use thereof | 德西费拉制药有限责任公司 | 2025-03-11 | — | — | CN | disclosed |
| CN-119585242-A | RAF kinase inhibitors and methods of use thereof | 德西费拉制药有限责任公司 | 2025-03-07 | — | — | CN | disclosed |
| EP-4444429-A1 | RAF KINASE INHIBITORS AND METHODS OF USE THEREOF | Deciphera Pharmaceuticals, LLC (US) | 2024-10-16 | — | — | EP | disclosed |
| WO-2023108108-A1 | RAF KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC (US) | 2023-06-15 | — | — | WO | disclosed |