Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20553506 | 0.83 | MAP4K4 (0.52) | GPR119JAK2EGFRJAK3MAP4K4 | |
| SCHEMBL23150443 | 0.82 | JAK2 (0.42) | MAPK1JAK2EGFRJAK3MAP4K4 | |
| SCHEMBL30405629 | 0.78 | JAK2 (0.54) | MAPK1JAK2EGFRJAK3MAP4K4 | |
| SCHEMBL30353312 | 0.76 | JAK3 (0.50) | JAK2JAK3FGFR1FGFR2FGFR3 | |
| SCHEMBL30405165 | 0.73 | FGFR1 (0.49) | JAK2JAK3FGFR1FGFR2FGFR3 | |
| SCHEMBL29867706 | 0.72 | PIK3CD (0.39) | JAK2EGFRJAK3OPRD1OPRK1 | |
| SCHEMBL29742069 | 0.69 | SMN1; SMN2 (0.47) | MAPTPOLBGPR119LMNASMN1; SMN2 | |
| SCHEMBL29742023 | 0.68 | SMN1; SMN2 (0.55) | POLBGPR119LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL29741845 | 0.68 | HRH3 (0.53) | MAPTPOLBGPR119LMNASMN1; SMN2 | |
| SCHEMBL28615895 | 0.66 | SMN1; SMN2 (0.48) | MAPTPOLBMAPK1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168002-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |