SCHEMBL3040756

SCHEMBL3040756

C[Si](C)(C)OCC#CC(=O)C(Cl)(Cl)Cl.O=C(C#CCOC1CCCCO1)C(Cl)(Cl)Cl

nearest known ligand 0.36

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
GCK P35557 1/20 0.34
KDM4C Q9H3R0 1/20 0.31
GRM5 P41594 1/20 0.30
RORC P51449 1/20 0.30
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL534143 0.91 MEN1 (0.38) MEN1KMT2AGCKGRM5RORC
SCHEMBL3763828 0.82 MEN1 (0.39) MEN1KMT2AGCKKDM4CGRM5
SCHEMBL3149260 0.78 MEN1 (0.38) MEN1KMT2AGCKGRM5RORC
SCHEMBL1412531 0.77 MEN1 (0.39) MEN1KMT2AGCKKDM4CGRM5
SCHEMBL24167283 0.77 MEN1 (0.44) MEN1KMT2AGCKKDM4CGRM5
SCHEMBL7188169 0.77 MEN1 (0.37) MEN1KMT2AGCKGRM5
SCHEMBL15273799 0.76 MEN1 (0.39) MEN1KMT2AGCKKDM4CGRM5
SCHEMBL1412418 0.75 MEN1 (0.38) MEN1KMT2AGCKGRM5NPC1
SCHEMBL1513547 0.73 MEN1 (0.36) MEN1KMT2AGCKGRM5NPC1
SCHEMBL10576592 0.72 MEN1 (0.38) MEN1KMT2AGCKKDM4CGRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2243777-A1 Method for manufacturing Pyridyl-substituted pyrazoles Bayer CropScience AG (DE) 2010-10-27 EP disclosed