Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25349206 | 1.00 | HDAC1 (0.44) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL25352186 | 0.92 | HDAC1 (0.46) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL24215838 | 0.90 | UCHL5 (0.49) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL30409726 | 0.90 | UCHL5 (0.49) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL25350185 | 0.89 | HDAC6 (0.52) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL25350937 | 0.89 | HDAC6 (0.44) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL25992763 | 0.88 | HDAC1 (0.42) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL25993048 | 0.88 | KDM4E (0.42) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL25993017 | 0.88 | KDM4E (0.52) | HDAC1HDAC6HDAC3HDAC2HDAC10 | |
| SCHEMBL24216545 | 0.87 | KDM4E (0.44) | HDAC1HDAC6HDAC3HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4185586-A1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Chong Kun Dang Pharmaceutical Corp. (KR) | 2023-05-31 | — | — | EP | disclosed |
| CN-116133658-A | Novel compounds as inhibitors of histone deacetylase 6 and pharmaceutical compositions comprising the same | 株式会社 钟根堂 | 2023-05-16 | — | — | CN | disclosed |