Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.45 |
| ▸ | KLK1 | P06870 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.38 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29029771 | 1.00 | ADRA1D (0.48) | ADRA1DCCR2MAPK8KLKB1KLK1 | |
| SCHEMBL6699063 | 0.88 | ADRA1D (0.49) | ADRA1DCCR2MAPK8KLKB1KLK1 | |
| SCHEMBL7054203 | 0.85 | ADRA1D (0.49) | ADRA1DCCR2MAPK8KLKB1KLK1 | |
| SCHEMBL8575180 | 0.84 | PLA2G2A (0.46) | ADRA1DPLA2G10CYP19A1 | |
| SCHEMBL29862301 | 0.83 | PLA2G2A (0.52) | ADRA1DCCR2PLA2G10 | |
| SCHEMBL818699 | 0.83 | PLA2G2A (0.52) | ADRA1DCCR2PLA2G10 | |
| SCHEMBL6774631 | 0.83 | ADRA1D (0.44) | ADRA1DCCR2MAPK8KLKB1KLK1 | |
| SCHEMBL30411505 | 0.83 | MAPK8 (0.42) | MAPK8KLK1FAAHPLA2G10 | |
| SCHEMBL29029780 | 0.83 | ADRA1D (0.46) | ADRA1DMAPK8KLK1FEN1POLB | |
| SCHEMBL30410966 | 0.83 | ADRA1D (0.46) | ADRA1DMAPK8KLK1FEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116585306-A | PLA2 inhibitors for immediate treatment of hymenoptera toxicity and other conditions due to histamine release | 奥菲瑞克斯股份有限公司 | 2023-08-15 | — | — | CN | disclosed |
| CN-109562098-B | PLA2 inhibitors for immediate treatment of hymenoptera toxicity and other conditions due to histamine release | 奥菲瑞克斯股份有限公司 | 2023-04-21 | — | — | CN | disclosed |