SCHEMBL30410141

SCHEMBL30410141

Cc1ccc(C=O)c(C)c1C(F)F

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.39
TSHR P16473 1/20 0.39
KCNJ1 P48048 2/20 0.35
TYR P14679 1/20 0.32
MEN1 O00255 1/20 0.31
LMNA P02545 1/20 0.31
THRB P10828 1/20 0.31
BLM P54132 1/20 0.31
KMT2A Q03164 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
NPC1 O15118 1/20 0.30
PKM P14618 1/20 0.30
RAB9A P51151 1/20 0.30
TRIM24 O15164 1/20 0.30
TRIM33 Q9UPN9 1/20 0.30
CYP1A2 P05177 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2D6 P10635 1/20 0.30
CYP2C19 P33261 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13980135 0.75 CYP1A2 (0.32) TSHRCYP1A2
SCHEMBL366594 0.73 ALDH1A1 (0.48) ALDH1A1TSHRKCNJ1TYRMEN1
SCHEMBL5233407 0.72 ALDH1A1 (0.43) ALDH1A1TSHRKCNJ1MEN1LMNA
SCHEMBL4353272 0.72 ALDH1A1 (0.50) ALDH1A1TSHRKCNJ1TYRMEN1
SCHEMBL12433427 0.72 CYP1A2 (0.33) TSHRCYP1A2
SCHEMBL29818681 0.72 ALDH1A1 (0.50) ALDH1A1TSHRKCNJ1TYRMEN1
Hydrochloric Acid SCHEMBL28212658 0.72 ALDH1A1 (0.46) ALDH1A1TSHRKCNJ1TYRMEN1
SCHEMBL29818730 0.70 ALDH1A1 (0.44) ALDH1A1TSHRKCNJ1TYRMEN1
SCHEMBL1708271 0.68 ALDH1A1 (0.43) ALDH1A1TSHRKCNJ1MEN1LMNA
SCHEMBL6438818 0.68 ALDH1A1 (0.43) ALDH1A1TSHRKCNJ1MEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116133658-A Novel compounds as inhibitors of histone deacetylase 6 and pharmaceutical compositions comprising the same 株式会社 钟根堂 2023-05-16 CN disclosed