Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.32 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL154414 | 0.84 | ALDH1A1 (0.44) | ALDH1A1TSHRKCNJ1TDP1MEN1 | |
| SCHEMBL584614 | 0.82 | ERN1 (0.42) | ALDH1A1TSHRKCNJ1TDP1MEN1 | |
| SCHEMBL5233407 | 0.82 | ALDH1A1 (0.43) | ALDH1A1TSHRKCNJ1TDP1MEN1 | |
| SCHEMBL19641559 | 0.80 | ALDH1A1 (0.41) | ALDH1A1TSHRKCNJ1TDP1MEN1 | |
| SCHEMBL12593983 | 0.78 | ERN1 (0.40) | ALDH1A1TSHRMEN1KMT2AERN1 | |
| SCHEMBL13743324 | 0.78 | TSHR (0.36) | ALDH1A1TSHRKCNJ1TDP1MEN1 | |
| SCHEMBL17842808 | 0.78 | ALDH1A1 (0.40) | ALDH1A1TSHRKCNJ1TDP1MEN1 | |
| SCHEMBL19862054 | 0.78 | ALDH1A1 (0.35) | ALDH1A1TSHRKCNJ1TDP1MEN1 | |
| SCHEMBL14882565 | 0.78 | ERN1 (0.44) | ALDH1A1TSHRERN1TRIM24TRIM33 | |
| SCHEMBL18508549 | 0.78 | ALDH1A1 (0.40) | ALDH1A1TSHRKCNJ1TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10370370-B2 | Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors | AXOVANT SCIENCES GMBH (CH) | 2019-08-06 | — | — | US | disclosed |
| US-10370370-B2 | Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors | AXOVANT SCIENCES GMBH (CH) | 2019-08-06 | — | — | US | disclosed |
| US-20180134696-A1 | Aminobenzisoxazole Compounds as Agonists of Alpha7-Nicotinic Acetylcholine Receptors | FORUM PHARMACEUTICALS, INC. | 2018-05-17 | — | — | US | disclosed |
| US-20180134696-A1 | Aminobenzisoxazole Compounds as Agonists of Alpha7-Nicotinic Acetylcholine Receptors | FORUM PHARMACEUTICALS, INC. | 2018-05-17 | — | — | US | disclosed |
| US-20180134696-A1 | Aminobenzisoxazole Compounds as Agonists of Alpha7-Nicotinic Acetylcholine Receptors | FORUM PHARMACEUTICALS, INC. | 2018-05-17 | — | — | US | disclosed |
| EP-3307269-A1 | AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF A7-NICOTINIC ACETYLCHOLINE RECEPTORS | Axovant Sciences GmbH (DE) | 2018-04-18 | — | — | EP | disclosed |
| US-9562045-B2 | Process for preparation of indolizine based derivatives as potential phosphodiestrase 3 (PDE3) inhibitors | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-02-07 | — | — | US | disclosed |
| WO-2016201096-A1 | AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF A7-NICOTINIC ACETYLCHOLINE RECEPTORS | FORUM PHARMACEUTICALS, INC. (US) | 2016-12-15 | — | — | WO | disclosed |
| US-20160159792-A1 | PROCESS FOR PREPARATION OF INDOLIZINE BASED DERIVATIVES AS POTENTIAL PHOSPHODIESTRASE 3 (PDE3) INHIBITORS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-06-09 | — | — | US | disclosed |
| US-20110104055-A1 | SUBSTITUTED N-ARYL BENZAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES | PROTEOTECH INC. | 2011-05-05 | — | — | US | disclosed |
| CN-1211340-C | Process for preparing fluorinated and chlorinated benzaldehydes and compositions thereof | MILLIKEN & CO (US) | 2005-07-20 | — | — | CN | disclosed |
| EP-1313690-B1 | METHOD OF PRODUCING FLUORINATED AND CHLORINATED BENZALDEHYDES | MILLIKEN & CO (US) | 2005-04-06 | — | — | EP | disclosed |
| CN-1449368-A | Method of producing fluorinated and chlorinated benzaldehydes and compositions thereof | MILLIKEN & CO (US) | 2003-10-15 | — | — | CN | disclosed |
| EP-1313691-A2 | FLUORINATED AND CHLORINATED BENZALDEHYDES | Milliken & Company (US) | 2003-05-28 | — | — | EP | disclosed |
| EP-1313690-A1 | METHOD OF PRODUCING FLUORINATED AND CHLORINATED BENZALDEHYDES AND COMPOSITIONS THEREOF | Milliken & Company (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002020452-A2 | NOVEL FLUORINATED AND CHLORINATED BENZALDEHYDES | MILLIKEN & COMPANY (US) | 2002-03-14 | — | — | WO | disclosed |
| WO-2002020447-A1 | METHOD OF PRODUCING FLUORINATED AND CHLORINATED BENZALDEHYDES AND COMPOSITIONS THEREOF | MILLIKEN & COMPANY (US) | 2002-03-14 | — | — | WO | disclosed |
| US-6300525-B1 | CONTACTING SUBSTITUTED BENZENE IN CARBON MONOXIDE ATMOSPHERE HAVING SPECIFIED PRESSURE IN PRESENCE OF METAL HALIDE AND HYDROHALIC ACID CATALYST AND AT SPECIFIED TEMPERATURE | MILLIKEN & COMPANY | 2001-10-09 | — | — | US | disclosed |
| US-6297405-B1 | EFFICIENTLY PRODUCED BENZALDEHYDE CHEMICAL INTERMEDIATE SUBSTITUTED BY ONE HALOGEN AND ALKYL OR CYCLOALKYL GROUPS AT OTHER POSITIONS | MILLIKEN & COMPANY | 2001-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10370370-B2 | Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors | CHRNA7, CHRNA5, CHRNA2 | ALDH1A1 2556/4885TSHR 779/4885KCNJ1 1009/4885 |
| US-20110104055-A1 | SUBSTITUTED N-ARYL BENZAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES | IAPP, SNCA, BACE2 | ALDH1A1 2495/4885TSHR 4061/4885KCNJ1 880/4885 |
| US-20160159792-A1 | PROCESS FOR PREPARATION OF INDOLIZINE BASED DERIVATIVES AS POTENTIAL PHOSPHODIESTRASE 3 (PDE3) INHIBITORS | PDE3A, PDE5A, PDE3B | ALDH1A1 828/4885TSHR 4109/4885KCNJ1 2984/4885 |
| US-20180134696-A1 | Aminobenzisoxazole Compounds as Agonists of Alpha7-Nicotinic Acetylcholine Receptors | CHRNA7, CHRNA5, CHRNA2 | ALDH1A1 2821/4885TSHR 808/4885KCNJ1 1408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.