Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 4/20 | 0.55 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 11/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.36 |
| ▸ | ABL1 | P00519 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3599442 | 0.82 | NUDT1 (0.63) | JAK1NUDT1CHEK1AKT1AKT2 | |
| SCHEMBL18366732 | 0.72 | FYN (0.45) | JAK1NUDT1CHEK1EGLN2 | |
| SCHEMBL2791338 | 0.72 | JAK1 (0.68) | JAK1 | |
| SCHEMBL30411003 | 0.70 | JAK1 (0.74) | JAK1 | |
| SCHEMBL18366704 | 0.69 | NUDT1 (0.38) | JAK1NUDT1EGLN2 | |
| SCHEMBL2238524 | 0.67 | JAK1 (1.00) | JAK1 | |
| SCHEMBL28530395 | 0.65 | AHR (0.54) | NUDT1 | |
| SCHEMBL31403778 | 0.64 | MKNK1 (0.62) | CHEK1AKT1AKT2CHEK2ABL1 | |
| SCHEMBL29636234 | 0.63 | — | — | |
| SCHEMBL32664865 | 0.63 | NUDT1 (0.39) | JAK1NUDT1CHEK1AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111320624-B | Triazolopyridine and imidazopyridine compounds, and preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2023-05-12 | — | — | CN | disclosed |