Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 17/20 | 1.00 |
| ▸ | DRD1 | P21728 | 9/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 5/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 3/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 3/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 3/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 3/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | MTOR | P42345 | 2/20 | 1.00 |
| ▸ | DRD3 | P35462 | 4/20 | 0.76 |
| ▸ | DRD4 | P21917 | 3/20 | 0.76 |
| ▸ | DRD5 | P21918 | 3/20 | 0.76 |
| ▸ | HRH1 | P35367 | 3/20 | 0.76 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| N-Desmethylclozapine SCHEMBL29365906 | 1.00 | DRD2 (1.00) | DRD2DRD1CHRM1CYP1A2CHRM2 | |
| N-Desmethylclozapine SCHEMBL781423 | 1.00 | DRD2 (1.00) | DRD2DRD1CHRM1CYP1A2CHRM2 | |
| N-Desmethylclozapine SCHEMBL29360816 | 1.00 | DRD2 (1.00) | DRD2DRD1CHRM1CYP1A2CHRM2 | |
| SCHEMBL3431059 | 0.95 | DRD2 (0.91) | DRD2DRD1CHRM1CYP1A2CHRM2 | |
| SCHEMBL20887469 | 0.92 | DRD2 (0.88) | DRD2DRD1CHRM1CYP1A2CHRM2 | |
| SCHEMBL3411298 | 0.91 | DRD2 (0.83) | DRD2DRD1CHRM1CYP1A2CHRM2 | |
| SCHEMBL3408005 | 0.90 | DRD2 (0.82) | DRD2DRD1CHRM1CYP1A2CHRM2 | |
| SCHEMBL3411946 | 0.90 | DRD2 (0.82) | DRD2DRD1CHRM1CYP1A2CHRM2 | |
| SCHEMBL3407780 | 0.90 | DRD2 (0.81) | DRD2DRD1CHRM1CYP1A2CHRM2 | |
| SCHEMBL3411880 | 0.89 | DRD2 (0.80) | DRD2DRD1CHRM1CYP1A2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023111877-A1 | A STABLE EXTENDED RELEASE PHARMACEUTICAL COMPOSITION OF CLOZAPINE | INTAS PHARMACEUTICALS LTD. (IN) | 2023-06-22 | — | — | WO | disclosed |