Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.43 |
| ▸ | GABRE | P78334 | 1/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31430855 | 1.00 | KDR (0.47) | KDRSMN1; SMN2LMNAKEAP1NFE2L2 | |
| Nitrous Acid SCHEMBL27969638 | 0.93 | KDR (0.43) | KDRSMN1; SMN2LMNAKEAP1NFE2L2 | |
| SCHEMBL28007123 | 0.84 | KDR (0.50) | KDRSMN1; SMN2LMNAHCAR2KDM4E | |
| SCHEMBL13964183 | 0.84 | KDR (0.47) | KDRSMN1; SMN2LMNAHCAR2KDM4E | |
| SCHEMBL25841888 | 0.82 | PARP1 (0.50) | KDR | |
| SCHEMBL2280055 | 0.80 | FTO (0.43) | SMN1; SMN2LMNAKEAP1NFE2L2GABRP | |
| SCHEMBL3732128 | 0.79 | ATM (0.47) | KDRSMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL8828399 | 0.79 | PIK3C3 (0.49) | KDRALDH1A1KMT2AHPGD | |
| SCHEMBL612856 | 0.79 | KDM4E (0.48) | SMN1; SMN2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL915781 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAKEAP1NFE2L2HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 180 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12508268-B2 | Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy | AUCKLAND UNISERVICES LIMITED (NZ) | 2025-12-30 | — | — | US | disclosed |
| US-20250066378-A1 | SPIRO-OXAZOLONES | HOFFMANN-LA ROCHE INC. (US) | 2025-02-27 | — | — | US | disclosed |
| CN-118126043-B | PLK4 inhibitor with high selectivity and preparation method and application thereof | 沈阳药科大学 | 2025-01-28 | — | — | CN | disclosed |
| WO-2025007784-A1 | HETEROAROMATIC RING COMPOUND, PHARMACEUTICAL COMPOSITION, PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2025-01-09 | — | — | WO | disclosed |
| US-12162887-B2 | Spiro-oxazolones | HOFFMANN-LA ROCHE INC. (US) | 2024-12-10 | — | — | US | disclosed |
| US-20240285641-A1 | INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 and TDO) AND THEIR USE IN THERAPY | AUCKLAND UNISERVICES LIMITED (NZ) | 2024-08-29 | — | — | US | disclosed |
| WO-2024129395-A1 | BTK INHIBITORS | GWYNANT THERAPEUTICS, INC. (US) | 2024-06-20 | — | — | WO | disclosed |
| WO-2024114574-A1 | HIGH-SELECTIVITY PLK4 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 沈阳药科大学 | 2024-06-06 | — | — | WO | disclosed |
| CN-118126043-A | PLK4 inhibitor with high selectivity and preparation method and application thereof | 沈阳药科大学 | 2024-06-04 | — | — | CN | disclosed |
| CN-117618423-A | Inhibitors of tryptophan dioxygenase (IDO 1 and TDO) and their use in therapy | 奥克兰联合服务有限公司 | 2024-03-01 | — | — | CN | disclosed |
| US-20050020611-A1 | Compounds | PFIZER INC. | 2005-01-27 | — | — | US | disclosed |
| US-5405826-A | Herbicidal pyridopyridazinones and pyridopyridazinethiones | RHONE POULENC AGRICULTURE LIMITED (GB) | 1995-04-11 | — | — | US | disclosed |
| US-5393730-A | Preemergence, postemergence herbicides | RHONE-POULENC AGRICULTURE LTD. (GB) | 1995-02-28 | — | — | US | disclosed |
| CN-1098096-A | New nicotinic acid derivatives | RHONE POULENC AGRICULTURE (GB) | 1995-02-01 | — | — | CN | disclosed |
| EP-0606843-A1 | Nicotinic acid derivative | RHONE POULENC AGRICULTURE LTD. (GB) | 1994-07-20 | — | — | EP | disclosed |
| CN-1076448-A | Novel herbicide | R P AGRICULTURE LTD (GB) | 1993-09-22 | — | — | CN | disclosed |
| EP-0555957-A1 | Pyrido 2,3-d pyridazine derivatives as herbicides | RHONE-POULENC AGRICULTURE LTD. (GB) | 1993-08-18 | — | — | EP | disclosed |
| EP-0482481-A1 | Method for the preparation of 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepines | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1992-04-29 | — | — | EP | disclosed |
| EP-0295833-A1 | Aromatic-Spiropiperidine oxazepinones (and thiones) | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1988-12-21 | — | — | EP | disclosed |
| US-4746655-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1988-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020611-A1 | Compounds | NQO1, NAMPT, NNT | KDR 3071/4885SMN1; SMN2 2287/4885LMNA 915/4885 |
| US-20240285641-A1 | INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 and TDO) AND THEIR USE IN THERAPY | IDO1, TDO2, IDO2 | KDR 3759/4885SMN1; SMN2 3658/4885LMNA 4683/4885 |
| US-12508268-B2 | Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy | IDO1, IDO2, TDO2 | KDR 922/4885SMN1; SMN2 3177/4885LMNA 4304/4885 |
| US-12162887-B2 | Spiro-oxazolones | AVPR1A, AVPR1B, AVPR2 | KDR 1094/4885SMN1; SMN2 3497/4885LMNA 3114/4885 |
| US-20250066378-A1 | SPIRO-OXAZOLONES | AVPR1A, AVPR1B, AVPR2 | KDR 1094/4885SMN1; SMN2 3497/4885LMNA 3114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.