SCHEMBL30416827

SCHEMBL30416827

CC(C)(C)OC(=O)N1CC(c2ccc(Br)cc2Cl)C1

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
USP30 Q70CQ3 3/20 0.48
KDM4E B2RXH2 1/20 0.46
FPR2 P25090 3/20 0.43
RORC P51449 2/20 0.42
CNR1 P21554 1/20 0.42
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
STS P08842 1/20 0.41
NAMPT P43490 1/20 0.40
FPR3 P25089 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
BACE1 P56817 1/20 0.39
HTT P42858 1/20 0.39
RECQL P46063 1/20 0.39
ESR2 Q92731 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23623173 1.00 USP30 (0.48) USP30KDM4EFPR2RORCCNR1
SCHEMBL23612159 0.93 KDM4E (0.44) USP30KDM4EFPR2RORCCNR1
SCHEMBL23291499 0.88 STS (0.50) USP30KDM4EFPR2CNR1MEN1
SCHEMBL15168346 0.86 USP30 (0.49) USP30KDM4EFPR2RORCMEN1
SCHEMBL19202529 0.86 ESR2 (0.51) USP30KDM4ECNR1MEN1KMT2A
SCHEMBL30912590 0.85 NR1H2 (0.49) USP30KDM4ECNR1MEN1KMT2A
SCHEMBL22059962 0.85 KDM4E (0.46) USP30KDM4ECNR1MEN1KMT2A
SCHEMBL30700671 0.85 KDM4E (0.46) USP30KDM4ECNR1MEN1KMT2A
SCHEMBL38658196 0.84 GPR119 (0.46) USP30KDM4ECNR1MEN1KMT2A
SCHEMBL30271952 0.84 PDE4B (0.47) USP30KDM4EFPR2RORCSTS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260109702-A1 NOVEL GSPT PROTEIN DEGRADER AND APPLICATION THEREOF GENOSCO INC (US) 2026-04-23 US disclosed
US-20230127839-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY NOVARTIS PHARMA AG (CH) 2023-04-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260109702-A1 NOVEL GSPT PROTEIN DEGRADER AND APPLICATION THEREOF CRBN, PSMB3, PSMB1 USP30 156/4885KDM4E 2393/4885FPR2 4753/4885
US-20230127839-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY STING1, CGAS, IRF3 USP30 2353/4885KDM4E 3761/4885FPR2 2489/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.