Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monoethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | AOC2 | O75106 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL497602 | 0.88 | KDM4E (0.47) | MAPTGPR84KDM4ECYP1A2NOTUM | |
| Fluoride SCHEMBL31047191 | 0.86 | KDM4E (0.46) | MAPTGPR84KDM4ECYP1A2NOTUM | |
| SCHEMBL8642884 | 0.84 | SRC (0.40) | MAPTKDM4EALOX15NOTUMAOC2 | |
| Toluene SCHEMBL28427945 | 0.81 | GPR84 (0.44) | MAPTGPR84KDM4ENOTUMALDH1A1 | |
| SCHEMBL28149404 | 0.80 | NPSR1 (0.41) | MAPTGPR84KDM4ENOTUMALDH1A1 | |
| SCHEMBL10884019 | 0.79 | SRC (0.52) | MAPTGPR84KDM4ENOTUMALDH1A1 | |
| SCHEMBL27572156 | 0.79 | INPPL1 (0.44) | MAPTGPR84KDM4ECYP1A2NOTUM | |
| SCHEMBL21875815 | 0.79 | KDM4E (0.44) | MAPTGPR84KDM4ECYP1A2NOTUM | |
| SCHEMBL11145571 | 0.78 | ALDH1A1 (0.44) | MAPTKDM4ENOTUMALDH1A1NPSR1 | |
| SCHEMBL29070725 | 0.77 | KDM4E (0.43) | MAPTGPR84KDM4ECYP1A2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116143826-A | Novel boron liposome helpful for diagnosis and treatment | 北京大学 | 2023-05-23 | — | — | CN | claimed |
| CN-116143826-A | Novel boron liposome helpful for diagnosis and treatment | 北京大学 | 2023-05-23 | — | — | CN | disclosed |