Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 14/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 14/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25180870 | 1.00 | P2RX7 (0.40) | P2RX7GRIN1GRIN2BKDM4EALDH1A1 | |
| SCHEMBL30679591 | 0.85 | MET (0.46) | P2RX7GRIN1GRIN2BMETMEN1 | |
| SCHEMBL23528305 | 0.83 | GRIN1 (0.44) | P2RX7GRIN1GRIN2BKDM4EALDH1A1 | |
| SCHEMBL30420319 | 0.80 | P2RX7 (0.41) | P2RX7GRIN1GRIN2BKDM4EALDH1A1 | |
| SCHEMBL25415591 | 0.80 | GRIN1 (0.40) | P2RX7GRIN1GRIN2BKDM4EALDH1A1 | |
| SCHEMBL30419503 | 0.80 | GRIN1 (0.40) | P2RX7GRIN1GRIN2BKDM4EALDH1A1 | |
| SCHEMBL25417370 | 0.80 | P2RX7 (0.41) | P2RX7GRIN1GRIN2BKDM4EALDH1A1 | |
| SCHEMBL25416626 | 0.78 | P2RX7 (0.40) | P2RX7GRIN1GRIN2BKDM4EALDH1A1 | |
| SCHEMBL30419554 | 0.78 | P2RX7 (0.40) | P2RX7GRIN1GRIN2BKDM4EALDH1A1 | |
| SCHEMBL25418980 | 0.77 | MET (0.39) | P2RX7GRIN1GRIN2BMETMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4433473-A1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2024-09-25 | — | — | EP | disclosed |
| WO-2023091606-A1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |