SCHEMBL30423217

SCHEMBL30423217

O=C1CCCC2(CCN(c3cc(-n4ccc(C(F)(F)F)n4)ncn3)CC2)N1c1ccc(F)c(F)c1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MOGAT2 Q3SYC2 1/20 0.33
DPP4 P27487 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24253836 1.00 MOGAT2 (0.33) MOGAT2DPP4
SCHEMBL24253868 0.87 EGLN2 (0.32) DPP4
SCHEMBL30424470 0.87 EGLN2 (0.32) DPP4
SCHEMBL30424472 0.84 SLC34A1 (0.34) MOGAT2DPP4
SCHEMBL24253938 0.84 SLC34A1 (0.34) MOGAT2DPP4
SCHEMBL24253832 0.82 HCRTR2 (0.33) DPP4
SCHEMBL24253834 0.81 HCRTR1 (0.33) DPP4
SCHEMBL30424148 0.81 ELOVL1 (0.41) DPP4
SCHEMBL24253644 0.81 ELOVL1 (0.41) DPP4
SCHEMBL24253540 0.81 HCRTR1 (0.34) DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4196478-A1 HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF Novartis AG (CH) 2023-06-21 EP claimed
CN-116157404-A Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof 诺华股份有限公司 2023-05-23 CN claimed
EP-4196478-A1 HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF Novartis AG (CH) 2023-06-21 EP disclosed
CN-116157404-A Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof 诺华股份有限公司 2023-05-23 CN disclosed