SCHEMBL30423263

SCHEMBL30423263

C=CC(=O)Nc1cccc(Nc2ncnc(Nc3ccc(C(=O)Nc4ccccn4)cc3)n2)c1

nearest known ligand 0.67

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
EGFR P00533 13/20 0.67
BTK Q06187 11/20 0.67
ITK Q08881 4/20 0.61
BLK P51451 2/20 0.61
SRC P12931 1/20 0.61
NPC1 O15118 1/20 0.50
RAB9A P51151 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28399244 1.00 EGFR (0.67) EGFRBTKITKBLKSRC
SCHEMBL28406583 0.85 EGFR (0.58) EGFRBTKITKBLKSRC
SCHEMBL30423271 0.85 EGFR (0.58) EGFRBTKITKBLKSRC
SCHEMBL17675258 0.80 EGFR (1.00) EGFRBTKBLKSRC
SCHEMBL30423295 0.79 EGFR (0.75) EGFRBTKITKBLKSRC
SCHEMBL28400978 0.79 EGFR (0.75) EGFRBTKITKBLKSRC
SCHEMBL17675435 0.78 EGFR (0.84) EGFRBTKBLKSRC
SCHEMBL28397630 0.78 BTK (0.61) EGFRBTKITKBLKSRC
SCHEMBL6483156 0.77 EGFR (0.64) EGFRBTKITKBLKSRC
SCHEMBL17675227 0.77 EGFR (0.75) EGFRBTKBLKSRCNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111057021-B S-triazine compound, preparation method and application thereof 中国药科大学 2023-05-23 CN claimed
CN-111057021-B S-triazine compound, preparation method and application thereof 中国药科大学 2023-05-23 CN disclosed