SCHEMBL30423271

SCHEMBL30423271

C=CC(=O)Nc1cccc(Nc2ncnc(Nc3ccc(C(=O)Nc4ccc(C)cn4)cc3)n2)c1

nearest known ligand 0.58

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
EGFR P00533 13/20 0.58
BTK Q06187 8/20 0.58
ITK Q08881 5/20 0.58
BLK P51451 2/20 0.58
SRC P12931 1/20 0.58
PIP4K2A P48426 1/20 0.50
PIP4K2B P78356 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28406583 1.00 EGFR (0.58) EGFRBTKITKBLKSRC
SCHEMBL28399244 0.85 EGFR (0.67) EGFRBTKITKBLKSRC
SCHEMBL30423263 0.85 EGFR (0.67) EGFRBTKITKBLKSRC
SCHEMBL28397441 0.79 BTK (0.60) EGFRBTKITKBLKSRC
SCHEMBL27831677 0.77 ITK (0.86) EGFRBTKITK
SCHEMBL28080977 0.77 BTK (0.88) EGFRBTKITK
SCHEMBL16188453 0.76 BTK (0.82) EGFRBTKBLK
SCHEMBL28397630 0.75 BTK (0.61) EGFRBTKITKBLKSRC
SCHEMBL27831797 0.75 EGFR (0.84) EGFRBTKITK
SCHEMBL6483156 0.75 EGFR (0.64) EGFRBTKITKBLKSRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111057021-B S-triazine compound, preparation method and application thereof 中国药科大学 2023-05-23 CN claimed
CN-111057021-B S-triazine compound, preparation method and application thereof 中国药科大学 2023-05-23 CN disclosed