Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.52 |
| ▸ | DPP4 | P27487 | 10/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 5/20 | 0.40 |
| ▸ | JAK3 | P52333 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25242164 | 1.00 | NUDT1 (0.52) | NUDT1DPP4ALDH1A1MEN1KMT2A | |
| SCHEMBL25222245 | 0.82 | NUDT1 (0.54) | NUDT1ALDH1A1MEN1KMT2AJAK2 | |
| SCHEMBL30989297 | 0.82 | NUDT1 (0.54) | NUDT1ALDH1A1MEN1KMT2AJAK2 | |
| SCHEMBL25233792 | 0.82 | NUDT1 (0.54) | NUDT1ALDH1A1MEN1KMT2AJAK2 | |
| SCHEMBL30989243 | 0.82 | NUDT1 (0.54) | NUDT1ALDH1A1MEN1KMT2AJAK2 | |
| SCHEMBL29266832 | 0.81 | KDM4C (0.39) | ALDH1A1MEN1KMT2A | |
| SCHEMBL25225152 | 0.79 | NUDT1 (0.45) | NUDT1 | |
| SCHEMBL30424272 | 0.79 | NUDT1 (0.45) | NUDT1 | |
| SCHEMBL11790619 | 0.71 | KDM4E (0.47) | NUDT1ALDH1A1MEN1KMT2A | |
| SCHEMBL15131223 | 0.71 | TSHR (0.56) | DPP4ALDH1A1TSHRHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4436957-A1 | THERAPEUTIC INDAZOLE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | Genentech, Inc. (US) | 2024-10-02 | — | — | EP | disclosed |
| CN-118302411-A | Therapeutic indazole compounds and methods of use thereof for the treatment of cancer | 基因泰克公司 | 2024-07-05 | — | — | CN | disclosed |
| WO-2023097195-A1 | THERAPEUTIC INDAZOLE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2023-06-01 | — | — | WO | disclosed |