Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 3/20 | 0.57 |
| ▸ | TEAD4 | Q15561 | 3/20 | 0.57 |
| ▸ | TEAD2 | Q15562 | 3/20 | 0.57 |
| ▸ | TEAD3 | Q99594 | 3/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GLS | O94925 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30469150 | 1.00 | TEAD1 (0.57) | TEAD1TEAD4TEAD2TEAD3SLC6A2 | |
| SCHEMBL25281888 | 0.85 | GRIA2 (0.45) | TEAD1TEAD4TEAD2TEAD3EPHX2 | |
| SCHEMBL30469100 | 0.85 | GRIA2 (0.45) | TEAD1TEAD4TEAD2TEAD3EPHX2 | |
| SCHEMBL30424432 | 0.85 | TEAD1 (0.60) | TEAD1TEAD4TEAD2TEAD3SLC6A4 | |
| SCHEMBL25239105 | 0.85 | TEAD1 (0.60) | TEAD1TEAD4TEAD2TEAD3SLC6A4 | |
| Hydrochloric Acid SCHEMBL25237493 | 0.84 | TEAD1 (0.59) | TEAD1TEAD4TEAD2TEAD3SLC6A4 | |
| SCHEMBL30469096 | 0.83 | TEAD1 (0.61) | TEAD1TEAD4TEAD2TEAD3EPHX2 | |
| SCHEMBL25232419 | 0.83 | TEAD1 (0.61) | TEAD1TEAD4TEAD2TEAD3EPHX2 | |
| SCHEMBL25749012 | 0.83 | TEAD1 (0.63) | TEAD1TEAD4TEAD2TEAD3EPHX2 | |
| SCHEMBL25237292 | 0.81 | TEAD1 (0.61) | TEAD1TEAD4TEAD2TEAD3EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023122782-A2 | INDOLES, INDAZOLES, AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD | THE KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2023-06-29 | — | — | WO | disclosed |
| US-20230202985-A1 | Indoles, Indazoles, and Related Analogs for Inhibiting YAP/TAZ-TEAD | CISTIM LEUVEN VZW (BE) | 2023-06-29 | — | — | US | disclosed |
| US-20230202985-A1 | Indoles, Indazoles, and Related Analogs for Inhibiting YAP/TAZ-TEAD | CISTIM LEUVEN VZW (BE) | 2023-06-29 | — | — | US | disclosed |
| US-20230202985-A1 | Indoles, Indazoles, and Related Analogs for Inhibiting YAP/TAZ-TEAD | CISTIM LEUVEN VZW (BE) | 2023-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230202985-A1 | Indoles, Indazoles, and Related Analogs for Inhibiting YAP/TAZ-TEAD | YAP1, TEAD2, TEAD3 | TEAD1 4/4885TEAD4 5/4885TEAD2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.