Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.55 |
| ▸ | TEK | Q02763 | 9/20 | 0.44 |
| ▸ | KDR | P35968 | 8/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25241512 | 1.00 | HDAC6 (0.55) | HDAC6TEKKDREPHB4HDAC3 | |
| SCHEMBL30425120 | 0.87 | HDAC6 (0.48) | HDAC6HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL25267008 | 0.87 | HDAC6 (0.48) | HDAC6HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL30425502 | 0.86 | UCHL5 (0.56) | HDAC6TEKKDRHDAC3HDAC1 | |
| SCHEMBL25207943 | 0.86 | UCHL5 (0.56) | HDAC6TEKKDRHDAC3HDAC1 | |
| SCHEMBL25992740 | 0.85 | TEK (0.61) | HDAC6TEKKDREPHB4NPC1 | |
| SCHEMBL25350756 | 0.85 | HDAC6 (0.53) | HDAC6TEKKDREPHB4HDAC3 | |
| SCHEMBL30409508 | 0.84 | HDAC6 (0.55) | HDAC6TEKKDREPHB4NPC1 | |
| SCHEMBL24216740 | 0.84 | HDAC6 (0.55) | HDAC6TEKKDREPHB4NPC1 | |
| SCHEMBL25216837 | 0.84 | HDAC6 (0.55) | HDAC6TEKKDREPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116157398-B | Oxadiazole-based selective histone deacetylase 6 inhibitors | 意大发马克股份公司 | 2025-03-11 | — | — | CN | claimed |
| CN-116157398-A | 2- (4- ((5- (benzo [ b ] thiophen-3-yl) -1H-tetrazol-1-yl) methyl) phenyl) -5- (difluoromethyl) -1,3, 4-oxadiazole derivatives and similar compounds as selective inhibitors of histone deacetylase 6 (HDAC 6) for the treatment of, for example, peripheral neuropathy | 意大发马克股份公司 | 2023-05-23 | — | — | CN | claimed |
| CN-116157398-B | Oxadiazole-based selective histone deacetylase 6 inhibitors | 意大发马克股份公司 | 2025-03-11 | — | — | CN | disclosed |
| CN-116157398-A | 2- (4- ((5- (benzo [ b ] thiophen-3-yl) -1H-tetrazol-1-yl) methyl) phenyl) -5- (difluoromethyl) -1,3, 4-oxadiazole derivatives and similar compounds as selective inhibitors of histone deacetylase 6 (HDAC 6) for the treatment of, for example, peripheral neuropathy | 意大发马克股份公司 | 2023-05-23 | — | — | CN | disclosed |