Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
| ▸ | GABRE | P78334 | 1/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23535454 | 1.00 | TSHR (0.60) | TSHRHSD17B10LMNACYP3A4KDM4E | |
| SCHEMBL30427332 | 0.85 | DPP4 (0.45) | TSHRHSD17B10CYP3A4KDM4EKMT2A | |
| SCHEMBL19329324 | 0.85 | DPP4 (0.45) | TSHRHSD17B10CYP3A4KDM4EKMT2A | |
| SCHEMBL16333723 | 0.82 | LCK (0.55) | TSHRHSD17B10KDM4EMAPTHTT | |
| SCHEMBL31492972 | 0.82 | TSHR (0.41) | TSHRHSD17B10KDM4EKMT2AHTT | |
| SCHEMBL31493111 | 0.82 | HSD17B10 (0.41) | TSHRHSD17B10KDM4EGABRPGABRD | |
| SCHEMBL31492990 | 0.80 | KDM4E (0.45) | LMNAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2828736 | 0.79 | TSHR (0.75) | TSHRHSD17B10LMNACYP3A4KDM4E | |
| SCHEMBL31493053 | 0.79 | TSHR (0.37) | TSHRHSD17B10KDM4EMAPTGABRP | |
| SCHEMBL32667097 | 0.79 | TSHR (0.38) | TSHRHSD17B10GABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4433457-A1 | HETEROCYCLIC AMIDES AND METHODS OF USING THE SAME | Rgenta Therapeutics, Inc. (US) | 2024-09-25 | — | — | EP | disclosed |
| WO-2023092098-A1 | HETEROCYCLIC AMIDES AND METHODS OF USING THE SAME | RGENTA THERAPEUTICS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |