Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975599 | 0.81 | KDM4E (0.51) | KDM4ESMN1; SMN2ALDH1A1PKMNPC1 | |
| SCHEMBL20049567 | 0.81 | MCHR1 (0.54) | NPC1RAB9AKMT2AHRH3CYP3A4 | |
| SCHEMBL29372575 | 0.79 | PDE10A (0.45) | KDM4ESMN1; SMN2ALDH1A1PKMNPC1 | |
| SCHEMBL31119524 | 0.78 | SCN9A (0.46) | KDM4EPKMNPC1RAB9APOLB | |
| SCHEMBL15004635 | 0.76 | HDAC1 (0.41) | KDM4ESMN1; SMN2ALDH1A1PKMNPC1 | |
| SCHEMBL24760172 | 0.75 | NPC1 (0.53) | KDM4ESMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL30259235 | 0.75 | IRAK4 (0.45) | KDM4ESMN1; SMN2ALDH1A1PKMNPC1 | |
| SCHEMBL12729868 | 0.75 | KDM4E (0.50) | KDM4ESMN1; SMN2ALDH1A1PKMNPC1 | |
| SCHEMBL16582016 | 0.75 | ALDH1A1 (0.41) | KDM4ESMN1; SMN2ALDH1A1PKMNPC1 | |
| SCHEMBL30259281 | 0.74 | IRAK4 (0.46) | KDM4ESMN1; SMN2ALDH1A1PKMNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4433457-A1 | HETEROCYCLIC AMIDES AND METHODS OF USING THE SAME | Rgenta Therapeutics, Inc. (US) | 2024-09-25 | — | — | EP | disclosed |
| WO-2023092098-A1 | HETEROCYCLIC AMIDES AND METHODS OF USING THE SAME | RGENTA THERAPEUTICS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |