Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34463931 | 0.79 | POLB (0.42) | HDAC8POLBGBA1DDB1CRBN | |
| SCHEMBL16616098 | 0.76 | GBA1 (0.47) | HDAC8POLBGBA1 | |
| SCHEMBL31633626 | 0.73 | GBA1 (0.38) | HDAC8POLBGBA1 | |
| SCHEMBL22227942 | 0.70 | CYP1A2 (0.35) | — | |
| SCHEMBL30428125 | 0.65 | POLB (0.41) | HDAC8POLBGBA1 | |
| SCHEMBL17959206 | 0.64 | POLB (0.44) | HDAC8POLBGBA1 | |
| SCHEMBL28293435 | 0.63 | MAOA (0.45) | POLB | |
| SCHEMBL28588930 | 0.62 | GBA1 (0.42) | HDAC8POLBSLC6A2SLC6A3GBA1 | |
| SCHEMBL23477959 | 0.62 | POLB (0.46) | HDAC8POLBGBA1 | |
| SCHEMBL23477826 | 0.62 | POLB (0.42) | HDAC8POLBGBA1DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4456895-A2 | HETEROARYL COMPOUNDS AS INHIBITORS OF IRAK4, COMPOSITIONS AND APPLICATIONS THEREOF | Accro Bioscience (HK) Limited (HK) | 2024-11-06 | — | — | EP | disclosed |
| WO-2023130054-A2 | HETEROARYL COMPOUNDS AS INHIBITORS OF IRAK4, COMPOSITIONS AND APPLICATIONS THEREOF | ACCRO BIOSCIENCE (HK) LIMITED (CN) | 2023-07-06 | — | — | WO | disclosed |