Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1938803 | 1.00 | KMO (0.61) | KMOLMNAMEN1KMT2ATP53 | |
| SCHEMBL30429048 | 0.91 | KMO (0.61) | KMOLMNAMEN1KMT2ATP53 | |
| SCHEMBL16217822 | 0.91 | KMO (0.61) | KMOLMNAMEN1KMT2ATP53 | |
| SCHEMBL1939132 | 0.91 | CYP11B2 (0.59) | KMOLMNAMEN1KMT2ATP53 | |
| SCHEMBL30429279 | 0.91 | CYP11B2 (0.59) | KMOLMNAMEN1KMT2ATP53 | |
| SCHEMBL1937820 | 0.90 | KMO (0.76) | KMOTP53CYP11B2L3MBTL1MAPT | |
| SCHEMBL30429046 | 0.89 | KMO (0.65) | KMOKMT2AL3MBTL1MAPK7 | |
| SCHEMBL1939335 | 0.89 | KMO (0.65) | KMOKMT2AL3MBTL1MAPK7 | |
| SCHEMBL30428237 | 0.88 | MAPT (0.62) | KMOLMNAMEN1KMT2ATP53 | |
| SCHEMBL14742040 | 0.88 | MAPT (0.62) | KMOLMNAMEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116323583-A | Heterobiaryl compounds and imaging agents for imaging huntingtin | CHDI基金会股份有限公司 | 2023-06-23 | — | — | CN | disclosed |
| EP-4192819-A1 | HETEROBIARYL COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI Foundation, Inc. (US) | 2023-06-14 | — | — | EP | disclosed |