Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1940169 | 1.00 | KMO (0.60) | KMOKMT2APOLBMEN1CNR2 | |
| SCHEMBL30459341 | 0.86 | CNR2 (0.72) | KMOKMT2AMEN1CNR2SIRT2 | |
| SCHEMBL1937298 | 0.86 | CNR2 (0.72) | KMOKMT2AMEN1CNR2SIRT2 | |
| SCHEMBL30459563 | 0.85 | KMO (0.63) | KMOKMT2APOLBSIRT2KDM4E | |
| SCHEMBL14742362 | 0.85 | KMO (0.63) | KMOKMT2APOLBSIRT2KDM4E | |
| SCHEMBL1938689 | 0.84 | MAPT (0.64) | KMOKMT2APOLBMEN1CNR2 | |
| Hydrochloric Acid SCHEMBL1937303 | 0.83 | MAPT (0.62) | KMOKMT2APOLBMEN1CNR2 | |
| SCHEMBL1939325 | 0.82 | KMO (0.64) | KMOKMT2APOLBCNR2MAPT | |
| SCHEMBL1938480 | 0.82 | KMO (0.64) | KMOKMT2APOLBMEN1CNR2 | |
| SCHEMBL30429437 | 0.82 | KMO (0.64) | KMOKMT2APOLBCNR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116323583-A | Heterobiaryl compounds and imaging agents for imaging huntingtin | CHDI基金会股份有限公司 | 2023-06-23 | — | — | CN | disclosed |
| EP-4192819-A1 | HETEROBIARYL COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI Foundation, Inc. (US) | 2023-06-14 | — | — | EP | disclosed |