Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 8/20 | 0.72 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1939010 | 1.00 | KMO (0.72) | KMONPC1RAB9AMEN1KMT2A | |
| SCHEMBL14742249 | 0.86 | KMO (0.65) | KMOGRM4SIRT2 | |
| SCHEMBL30428424 | 0.86 | KMO (0.65) | KMOGRM4SIRT2 | |
| SCHEMBL30459341 | 0.85 | CNR2 (0.72) | KMONPC1RAB9AMEN1KMT2A | |
| SCHEMBL1937298 | 0.85 | CNR2 (0.72) | KMONPC1RAB9AMEN1KMT2A | |
| SCHEMBL30459563 | 0.84 | KMO (0.63) | KMORAB9AKMT2AGRM4SIRT2 | |
| SCHEMBL14742362 | 0.84 | KMO (0.63) | KMORAB9AKMT2AGRM4SIRT2 | |
| SCHEMBL1939177 | 0.84 | KMO (1.00) | KMOMEN1KMT2AGRM4 | |
| SCHEMBL14742157 | 0.80 | KMO (0.71) | KMO | |
| SCHEMBL30429616 | 0.80 | KMO (0.64) | KMONPC1RAB9AGRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116323583-A | Heterobiaryl compounds and imaging agents for imaging huntingtin | CHDI基金会股份有限公司 | 2023-06-23 | — | — | CN | disclosed |
| EP-4192819-A1 | HETEROBIARYL COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI Foundation, Inc. (US) | 2023-06-14 | — | — | EP | disclosed |