Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 3/20 | 0.64 |
| ▸ | CNR2 | P34972 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ATR | Q13535 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 3/20 | 0.48 |
| ▸ | JAK1 | P23458 | 3/20 | 0.48 |
| ▸ | TYK2 | P29597 | 3/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | SMO | Q99835 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1938480 | 1.00 | KMO (0.64) | KMOCNR2KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1938412 | 0.90 | KMO (0.73) | KMOCNR2KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1939325 | 0.88 | KMO (0.64) | KMOCNR2KMT2ASMN1; SMN2ATR | |
| SCHEMBL30429437 | 0.88 | KMO (0.64) | KMOCNR2KMT2ASMN1; SMN2ATR | |
| SCHEMBL1938689 | 0.87 | MAPT (0.64) | KMOCNR2KMT2AMEN1KCNMA1 | |
| SCHEMBL1938146 | 0.86 | KMO (0.62) | KMOCNR2KMT2AMEN1ATR | |
| SCHEMBL1938464 | 0.86 | KMO (0.62) | KMOCNR2SMN1; SMN2ATRCYP3A4 | |
| Hydrochloric Acid SCHEMBL1937303 | 0.86 | MAPT (0.62) | KMOCNR2KMT2AMEN1KCNMA1 | |
| SCHEMBL30459856 | 0.85 | KMO (0.67) | KMOCNR2SMN1; SMN2GRM4HDAC6 | |
| SCHEMBL1938363 | 0.85 | KMO (0.67) | KMOCNR2SMN1; SMN2GRM4HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116323583-A | Heterobiaryl compounds and imaging agents for imaging huntingtin | CHDI基金会股份有限公司 | 2023-06-23 | — | — | CN | disclosed |
| EP-4192819-A1 | HETEROBIARYL COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI Foundation, Inc. (US) | 2023-06-14 | — | — | EP | disclosed |