Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 10/20 | 0.67 |
| ▸ | CNR2 | P34972 | 2/20 | 0.53 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1938363 | 1.00 | KMO (0.67) | KMOCNR2GRM4HDAC6NPC1 | |
| SCHEMBL1937298 | 0.86 | CNR2 (0.72) | KMOCNR2GRM4HDAC6NPC1 | |
| SCHEMBL30459341 | 0.86 | CNR2 (0.72) | KMOCNR2GRM4HDAC6NPC1 | |
| SCHEMBL1938480 | 0.85 | KMO (0.64) | KMOCNR2GRM4HDAC6SMN1; SMN2 | |
| SCHEMBL30429433 | 0.85 | KMO (0.64) | KMOCNR2GRM4HDAC6SMN1; SMN2 | |
| SCHEMBL1938412 | 0.84 | KMO (0.73) | KMOCNR2GRM4HDAC6NPC1 | |
| SCHEMBL1939271 | 0.84 | KMO (0.70) | KMOCNR2 | |
| SCHEMBL30429198 | 0.83 | KMO (0.58) | KMOCNR2ADORA1ADORA2A | |
| SCHEMBL1940154 | 0.83 | KMO (0.58) | KMOCNR2ADORA1ADORA2A | |
| SCHEMBL1939325 | 0.82 | KMO (0.64) | KMOCNR2GRM4HDAC6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116323583-A | Heterobiaryl compounds and imaging agents for imaging huntingtin | CHDI基金会股份有限公司 | 2023-06-23 | — | — | CN | disclosed |