Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 9/20 | 0.49 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | GFER | P55789 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13108609 | 1.00 | KDM4E (0.50) | KDM4EHPGDALDH1A1THRBMAPT | |
| SCHEMBL14425012 | 0.80 | AR (0.51) | KDM4EHPGDALDH1A1THRBMAPT | |
| SCHEMBL30911271 | 0.79 | HSD17B10 (0.50) | KDM4EHPGDALDH1A1MAPTKMT2A | |
| SCHEMBL30547023 | 0.75 | ALDH1A1 (0.56) | KDM4EHPGDALDH1A1THRBMAPT | |
| SCHEMBL16688229 | 0.75 | KDM4E (0.57) | KDM4EHPGDALDH1A1THRBMAPT | |
| SCHEMBL13174592 | 0.75 | ALDH1A1 (0.56) | KDM4EHPGDALDH1A1THRBMAPT | |
| SCHEMBL21254707 | 0.74 | MAPT (0.73) | KDM4EHPGDALDH1A1THRBMAPT | |
| SCHEMBL28864918 | 0.74 | F2 (0.38) | KDM4ERAB9AKMT2AMEN1POLB | |
| SCHEMBL18489808 | 0.73 | KDM4E (0.63) | KDM4EHPGDALDH1A1MAPTAHR | |
| SCHEMBL13672545 | 0.73 | KIF11 (0.58) | KDM4EHPGDALDH1A1THRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116082435-A | Dipeptide and tripeptide immunoproteasome inhibitor and preparation method and pharmaceutical application thereof | 中国医学科学院药物研究所 | 2023-05-09 | — | — | CN | disclosed |