Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 3/20 | 0.66 |
| ▸ | TEAD4 | Q15561 | 3/20 | 0.66 |
| ▸ | TEAD2 | Q15562 | 3/20 | 0.66 |
| ▸ | TEAD3 | Q99594 | 3/20 | 0.66 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.44 |
| ▸ | RARG | P13631 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25237436 | 1.00 | TEAD1 (0.66) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL25750434 | 0.93 | TEAD1 (0.62) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL30469096 | 0.90 | TEAD1 (0.61) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL25232419 | 0.90 | TEAD1 (0.61) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL25237292 | 0.88 | TEAD1 (0.61) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL25749012 | 0.87 | TEAD1 (0.63) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL25247529 | 0.84 | TEAD1 (0.60) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL30431703 | 0.84 | TEAD1 (0.57) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL25238957 | 0.84 | TEAD1 (0.57) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL25747721 | 0.84 | RARG (0.48) | TEAD1TEAD4TEAD2TEAD3SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12110276-B2 | Pyrazolo compounds and methods of use thereof | GENENTECH, INC. (US) | 2024-10-08 | — | — | US | claimed |
| US-20230202984-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2023-06-29 | — | — | US | claimed |
| US-20250074881-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2025-03-06 | — | — | US | disclosed |
| US-12110276-B2 | Pyrazolo compounds and methods of use thereof | GENENTECH, INC. (US) | 2024-10-08 | — | — | US | disclosed |
| CN-118302411-A | Therapeutic indazole compounds and methods of use thereof for the treatment of cancer | 基因泰克公司 | 2024-07-05 | — | — | CN | disclosed |
| US-20230202984-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2023-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250074881-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | VHL, TP53, MCL1 | TEAD1 282/4885TEAD4 162/4885TEAD2 129/4885 |
| US-20230202984-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | VHL, TP53, MCL1 | TEAD1 282/4885TEAD4 162/4885TEAD2 129/4885 |
| US-12110276-B2 | Pyrazolo compounds and methods of use thereof | THPO, KLK3, TP53 | TEAD1 390/4885TEAD4 240/4885TEAD2 200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.