Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 3/20 | 0.61 |
| ▸ | TEAD4 | Q15561 | 3/20 | 0.61 |
| ▸ | TEAD2 | Q15562 | 3/20 | 0.61 |
| ▸ | TEAD3 | Q99594 | 3/20 | 0.61 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30469096 | 1.00 | TEAD1 (0.61) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL30431649 | 0.90 | TEAD1 (0.66) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL25237436 | 0.90 | TEAD1 (0.66) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL25749012 | 0.89 | TEAD1 (0.63) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL25750434 | 0.89 | TEAD1 (0.62) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL25237292 | 0.88 | TEAD1 (0.61) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL25247529 | 0.87 | TEAD1 (0.60) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL30469077 | 0.86 | LMNA (0.50) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL25274909 | 0.86 | LMNA (0.50) | TEAD1TEAD4TEAD2TEAD3PTGER4 | |
| SCHEMBL30431703 | 0.84 | TEAD1 (0.57) | TEAD1TEAD4TEAD2TEAD3PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023122782-A2 | INDOLES, INDAZOLES, AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD | THE KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2023-06-29 | — | — | WO | disclosed |
| US-20230202985-A1 | Indoles, Indazoles, and Related Analogs for Inhibiting YAP/TAZ-TEAD | CISTIM LEUVEN VZW (BE) | 2023-06-29 | — | — | US | disclosed |
| US-20230202985-A1 | Indoles, Indazoles, and Related Analogs for Inhibiting YAP/TAZ-TEAD | CISTIM LEUVEN VZW (BE) | 2023-06-29 | — | — | US | disclosed |
| US-20230202985-A1 | Indoles, Indazoles, and Related Analogs for Inhibiting YAP/TAZ-TEAD | CISTIM LEUVEN VZW (BE) | 2023-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230202985-A1 | Indoles, Indazoles, and Related Analogs for Inhibiting YAP/TAZ-TEAD | YAP1, TEAD2, TEAD3 | TEAD1 4/4885TEAD4 5/4885TEAD2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.