Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARG | P13631 | 2/20 | 0.48 |
| ▸ | RORC | P51449 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.44 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.44 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.44 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | USP7 | Q93009 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25747720 | 0.91 | RARG (0.47) | RARGRORCALDH1A1SMN1; SMN2ADORA3 | |
| SCHEMBL25237436 | 0.84 | TEAD1 (0.66) | RARGRORCSMN1; SMN2TEAD1TEAD4 | |
| SCHEMBL30431649 | 0.84 | TEAD1 (0.66) | RARGRORCSMN1; SMN2TEAD1TEAD4 | |
| SCHEMBL25747719 | 0.81 | RARG (0.45) | RARGRORCALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL25750434 | 0.77 | TEAD1 (0.62) | RARGRORCSMN1; SMN2TEAD1TEAD4 | |
| SCHEMBL25231312 | 0.75 | RORC (0.45) | RARGRORCALDH1A1ADORA3TEAD1 | |
| SCHEMBL25278823 | 0.75 | CCR1 (0.48) | RARGRORCLMNATEAD1TEAD4 | |
| SCHEMBL25274909 | 0.75 | LMNA (0.50) | RARGRORCLMNATEAD1TEAD4 | |
| SCHEMBL7658230 | 0.75 | LMNA (0.45) | RARGRORCALDH1A1LMNAADORA3 | |
| SCHEMBL30469077 | 0.75 | LMNA (0.50) | RARGRORCLMNATEAD1TEAD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230202984-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2023-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230202984-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | VHL, TP53, MCL1 | RARG 457/4885RORC 240/4885ALDH1A1 829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.