Sugi Predict

Sugi Predict / Compounds / SCHEMBL3043372

SCHEMBL3043372

SCHEMBL3043372

CNC(=O)[C@H]1CN(c2cc(F)c3nc(-n4ccc(=O)cc4)oc3c2)C(=O)O1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAOA P21397 6/20 0.37
▸ GRIN1 Q05586 2/20 0.34
▸ GRIN2B Q13224 2/20 0.34
▸ MAOB P27338 3/20 0.34
▸ LMNA P02545 1/20 0.33
▸ PTGS1 P23219 1/20 0.33
▸ CALML3 P27482 1/20 0.33
▸ SDHA P31040 1/20 0.33
▸ F10 P00742 1/20 0.33
▸ TSHR P16473 1/20 0.31
▸ MAPK1 P28482 1/20 0.31
▸ GABRP O00591 1/20 0.31
▸ GABRD O14764 1/20 0.31
▸ GABRA1 P14867 1/20 0.31
▸ GABRB1 P18505 1/20 0.31
▸ GABRG2 P18507 1/20 0.31
▸ GABRB3 P28472 1/20 0.31
▸ GABRA5 P31644 1/20 0.31
▸ GABRA3 P34903 1/20 0.31
▸ GABRA2 P47869 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3038917 0.89 MAOA (0.48) MAOAMAOBLMNAPTGS1CALML3
SCHEMBL3031998 0.84 MAOA (0.41) MAOAGRIN1GRIN2BMAOBLMNA
SCHEMBL3048624 0.84 MAOA (0.43) MAOAGRIN1GRIN2BMAOBLMNA
SCHEMBL3041917 0.84 MAOA (0.41) MAOAGRIN1GRIN2BMAOBLMNA
SCHEMBL3039820 0.83 MAOA (0.38) MAOAGRIN1GRIN2BMAOBLMNA
SCHEMBL3038551 0.81 MAOA (0.37) MAOAGRIN1GRIN2BMAOBLMNA
SCHEMBL3038235 0.80 MAOA (0.39) MAOAGRIN1GRIN2BMAOBLMNA
SCHEMBL3035116 0.80 MAOA (0.38) MAOAGRIN1GRIN2BMAOBLMNA
SCHEMBL3044465 0.77 MAOA (0.42) MAOAGRIN1GRIN2BMAOBLMNA
SCHEMBL3035104 0.75 MAOA (0.38) MAOAGRIN1GRIN2BMAOBLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040147760-A1 N-aryl-2-oxazolidinone-5-carboxamides and their derivatives PHARMACIA & UPJOHN COMPANY 2004-07-29 — — US claimed
US-7645781-B2 N-aryl-2-oxazolidinone-5-carboxamides and their derivatives PFIZER INC (US) 2010-01-12 — — US disclosed
US-20070015801-A1 N-aryl-2-oxazolidinone-5-carboxamides and their derivatives THOMAS RICHARD C 2007-01-18 — — US disclosed
US-7141588-B2 N-aryl-2-oxazolidinone-5-carboxamides and their derivatives PFIZER, INC. (US) 2006-11-28 — — US disclosed
US-20040147760-A1 N-aryl-2-oxazolidinone-5-carboxamides and their derivatives PHARMACIA & UPJOHN COMPANY 2004-07-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040147760-A1 N-aryl-2-oxazolidinone-5-carboxamides and their derivatives OXA1L, AADAC, MT-ND5 MAOA 957/4885GRIN1 1767/4885GRIN2B 888/4885
US-20070015801-A1 N-aryl-2-oxazolidinone-5-carboxamides and their derivatives OXA1L, AADAC, MT-ND5 MAOA 957/4885GRIN1 1767/4885GRIN2B 888/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.