Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.43 |
| ▸ | GABRP | O00591 | 3/20 | 0.43 |
| ▸ | GABRD | O14764 | 3/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.43 |
| ▸ | GABRE | P78334 | 3/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.43 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18725412 | 1.00 | MAPK1 (0.44) | MAPK1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL18725442 | 0.84 | MAPK1 (0.44) | MAPK1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL21622928 | 0.84 | MAPK1 (0.44) | MAPK1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL19835436 | 0.81 | MAPK1 (0.50) | MAPK1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL16318862 | 0.80 | MAPK1 (0.46) | MAPK1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL28475255 | 0.80 | KDM4E (0.42) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL21873493 | 0.78 | LCK (0.53) | MAPK1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL30031450 | 0.78 | MAPK1 (0.47) | MAPK1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL3936135 | 0.78 | MAPK1 (0.47) | MAPK1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL3244089 | 0.78 | MAPK1 (0.47) | MAPK1GABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3621615-B1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS AND METHODS OF USE THEREOF | ENANTA PHARM INC (US) | 2023-11-15 | — | — | EP | disclosed |
| CN-110869017-B | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof | 英安塔制药有限公司 | 2023-05-05 | — | — | CN | disclosed |