Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3577404 | 0.71 | AXL (0.48) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL22336047 | 0.65 | DYRK1A (0.43) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL2876033 | 0.65 | AXL (0.52) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL10964206 | 0.64 | GPR3 (0.56) | MAPTMEN1HTTKMT2A | |
| SCHEMBL14266837 | 0.63 | AXL (0.48) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL15654873 | 0.63 | AXL (0.48) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL29046404 | 0.63 | DYRK1A (0.35) | AXLMKNK1MKNK2ADORA2APDPK1 | |
| SCHEMBL29865573 | 0.63 | GPR3 (0.54) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL30433880 | 0.63 | ADORA2A (0.37) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL30433767 | 0.60 | ADORA2A (0.33) | AXLMKNK1MKNK2ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4426702-A1 | CONDENSED-PYRAZINE AMINE DERIVATIVES FOR TREATING SCA3 | Skyhawk Therapeutics, Inc. (US) | 2024-09-11 | — | — | EP | disclosed |
| WO-2023081858-A1 | CONDENSED-PYRAZINE AMINE DERIVATIVES FOR TREATING SCA3 | SKYHAWK THERAPEUTICS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |