Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.55 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.54 |
| ▸ | PDE1A | P54750 | 6/20 | 0.51 |
| ▸ | PDE1B | Q01064 | 6/20 | 0.51 |
| ▸ | PDE1C | Q14123 | 6/20 | 0.51 |
| ▸ | LTK | P29376 | 2/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | GRK5 | P34947 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.49 |
| ▸ | MST1R | Q04912 | 1/20 | 0.49 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4841633 | 0.77 | PDE3B (0.48) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL30268976 | 0.75 | ADORA2A (0.48) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL30361793 | 0.73 | PDE3B (0.44) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL23858671 | 0.72 | PDE3B (0.57) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL7422898 | 0.69 | KDM4E (0.55) | PDE5APDE3BPDE3ALTKALK | |
| SCHEMBL23858893 | 0.69 | PDE3B (0.48) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL30361845 | 0.69 | ADORA2A (0.44) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL30218238 | 0.69 | ADORA2A (0.44) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL3522789 | 0.68 | PDE5A (0.58) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL10845661 | 0.67 | NSD3 (0.49) | CLK4XDHKDRHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12528815-B2 | 5-amino-8-(4-pyridyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one compounds for use against cancer | NXERA PHARMA UK LIMITED (GB) | 2026-01-20 | — | — | US | disclosed |
| CN-115867280-B | 5-Amino-8- (4-pyridyl) - [1,2,4] triazolo [4,3-C ] pyrimidin-3-one compounds for anticancer use | 奈克斯拉制药英国有限公司 | 2025-05-27 | — | — | CN | disclosed |
| US-20230146483-A1 | 5-AMINO-8-(4-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMIDIN-3-ONE COMPOUNDS FOR USE AGAINST CANCER | NXERA PHARMA UK LIMITED (GB) | 2023-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230146483-A1 | 5-AMINO-8-(4-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMIDIN-3-ONE COMPOUNDS FOR USE AGAINST CANCER | ADORA2A, ADORA1, ADORA3 | PDE5A 163/4885PDE3B 251/4885PDE3A 180/4885 |
| US-12528815-B2 | 5-amino-8-(4-pyridyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one compounds for use against cancer | ADORA1, ADORA3, OPRL1 | PDE5A 1599/4885PDE3B 1664/4885PDE3A 1508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.