Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 2/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | GRK5 | P34947 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | MST1R | Q04912 | 1/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420880 | 0.80 | KDM4E (0.47) | KDM4EHPGDHSD17B10SMN1; SMN2RAB9A | |
| SCHEMBL18229915 | 0.78 | PDE3B (0.49) | KDM4EHPGDHSD17B10PDE3BPDE3A | |
| SCHEMBL3479430 | 0.78 | LTK (0.41) | PDE3BPDE3ALTKALKDYRK1B | |
| SCHEMBL30759507 | 0.78 | PDE3B (0.49) | KDM4EHPGDHSD17B10PDE3BPDE3A | |
| SCHEMBL30636803 | 0.71 | KDM4E (1.00) | KDM4EHPGDHSD17B10SMN1; SMN2RAB9A | |
| SCHEMBL10969790 | 0.71 | KDM4E (0.57) | KDM4EHPGDHSD17B10SMN1; SMN2RAB9A | |
| SCHEMBL2119422 | 0.71 | LTK (0.51) | HSD17B10PDE3BPDE3ALTKALK | |
| SCHEMBL4787828 | 0.71 | KDM4E (1.00) | KDM4EHPGDHSD17B10SMN1; SMN2RAB9A | |
| SCHEMBL4517379 | 0.70 | PDE5A (0.49) | HSD17B10PDE3BPDE3ALTKALK | |
| SCHEMBL30434733 | 0.69 | PDE5A (0.55) | KDM4EHPGDPDE3BPDE3ALTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999018106-A1 | NOVEL 1,2,4-TRIAZOLO[4,3-C]QUINAZOLIN-3-ONES AND 1,2,4-TRIAZOLO[4,3-C]QUINAZOLIN-3-THIONES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1999-04-15 | — | — | WO | disclosed |
| WO-1999018106-A1 | NOVEL 1,2,4-TRIAZOLO[4,3-C]QUINAZOLIN-3-ONES AND 1,2,4-TRIAZOLO[4,3-C]QUINAZOLIN-3-THIONES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1999-04-15 | — | — | WO | disclosed |
| US-4463007-A | ANTIALLERGENS | BASF AKTIENGESELLSCHAFT (DE) | 1984-07-31 | — | — | US | disclosed |