Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | BLM | P54132 | 2/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | MPO | P05164 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MC4R | P32245 | 2/20 | 0.51 |
| ▸ | MC5R | P33032 | 1/20 | 0.51 |
| ▸ | MC3R | P41968 | 1/20 | 0.51 |
| ▸ | APAF1 | O14727 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16057376 | 0.89 | KDM4E (0.65) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL27153460 | 0.83 | KDM4E (0.82) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL8059982 | 0.83 | KDM4E (0.82) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL6688035 | 0.83 | KDM4E (0.82) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL27522281 | 0.81 | KDM4E (0.89) | KDM4EMAPTKMT2ALMNATSHR | |
| SCHEMBL31436164 | 0.80 | KDM4E (0.69) | KDM4EMAPTKMT2ALMNATSHR | |
| SCHEMBL1132857 | 0.80 | KDM4E (0.69) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL27865136 | 0.80 | KDM4E (0.76) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL1487572 | 0.80 | KDM4E (0.76) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL26089756 | 0.79 | KDM4E (0.84) | KDM4EMAPTKMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028130-A2 | ANTIDEPRESSANT COMPOUNDS | CONCERT PHARMACEUTICALS, INC. (US) | 2010-03-11 | — | — | WO | disclosed |