Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 7/20 | 0.43 |
| ▸ | CCNH | P51946 | 7/20 | 0.43 |
| ▸ | MNAT1 | P51948 | 6/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.37 |
| ▸ | CCNK | O75909 | 3/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.34 |
| ▸ | CDK9 | P50750 | 3/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | GNRHR | P30968 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25258483 | 1.00 | CDK7 (0.43) | CDK7CCNHMNAT1DGAT1CCNK | |
| SCHEMBL25597470 | 0.84 | DGAT1 (0.38) | CDK7CCNHMNAT1DGAT1CCNT1 | |
| SCHEMBL29492508 | 0.84 | DGAT1 (0.38) | CDK7CCNHMNAT1DGAT1CCNT1 | |
| SCHEMBL28312445 | 0.82 | CCNT1 (0.44) | CDK7CCNHMNAT1DGAT1CCNT1 | |
| SCHEMBL21184629 | 0.81 | DGAT1 (0.43) | CDK7CCNHMNAT1DGAT1CCNT1 | |
| SCHEMBL30771939 | 0.81 | DGAT1 (0.43) | CDK7CCNHMNAT1DGAT1CCNT1 | |
| SCHEMBL28313373 | 0.78 | DGAT1 (0.39) | DGAT1P2RX7 | |
| SCHEMBL29498421 | 0.77 | DGAT1 (0.41) | CDK7CCNHMNAT1DGAT1 | |
| SCHEMBL25225754 | 0.77 | DGAT1 (0.41) | CDK7CCNHMNAT1DGAT1 | |
| SCHEMBL25221135 | 0.77 | CDK7 (0.48) | CDK7CCNHMNAT1CCNKCDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484871-B1 | PIPERIDINE DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS INC (US) | 2023-06-07 | — | — | EP | disclosed |