Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21045835 | 1.00 | TRPC6 (0.55) | TRPC6MAPTFFAR4CYP1A2CYP2C9 | |
| SCHEMBL23047422 | 0.89 | TRPC6 (0.52) | TRPC6MAPTFFAR4CYP1A2CYP2C9 | |
| SCHEMBL21045916 | 0.88 | TRPC6 (0.56) | TRPC6FFAR4FFAR1KDM5AKDM5B | |
| SCHEMBL5806655 | 0.87 | TRPC6 (0.53) | TRPC6MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL15776567 | 0.86 | CNR2 (0.55) | TRPC6MAPTFFAR4KDM5AKDM5B | |
| SCHEMBL17129495 | 0.85 | ALDH1A1 (0.46) | TRPC6MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL30440180 | 0.80 | TRPC6 (0.56) | TRPC6MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL21045812 | 0.80 | TRPC6 (0.56) | TRPC6MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL21045659 | 0.78 | TRPC6 (0.48) | TRPC6MAPTCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL21274211 | 0.77 | SLC6A4 (0.48) | SMN1; SMN2ALDH1A1MAPK1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111527078-B | Pyridinecarbonyl derivatives and their therapeutic use as TRPC6 inhibitors | 勃林格殷格翰国际公司 | 2023-06-02 | — | — | CN | disclosed |