Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17869373 | 1.00 | HRH4 (0.49) | HRH4HRH3HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL1263372 | 0.97 | HRH4 (0.49) | HRH4HRH3HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL30440467 | 0.97 | HRH4 (0.49) | HRH4HRH3HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL3104344 | 0.87 | HTR2C (0.57) | HRH4HTTALDH1A1KDM4EPIM1 | |
| SCHEMBL20280064 | 0.87 | HRH4 (0.65) | HRH4HRH3HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL25230198 | 0.87 | CYP11B2 (0.60) | HRH4HTTALDH1A1SMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL31061265 | 0.86 | HTR2C (0.58) | HRH4HTTALDH1A1KDM4EPIM1 | |
| SCHEMBL3108697 | 0.84 | HRH4 (0.46) | HRH4HTTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL25224739 | 0.82 | ENPP2 (0.53) | HRH4ALDH1A1KDM4ELMNAALOX12 | |
| SCHEMBL25235983 | 0.81 | HRH4 (0.41) | HRH4HTTALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023114539-A1 | AMINO CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |