Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | PTPN22 | Q9Y2R2 | 3/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.57 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | EIF4E | P06730 | 1/20 | 0.49 |
| ▸ | EIF4G1 | Q04637 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3044098 | 1.00 | MAP3K5 (0.59) | MAP3K5MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL3037227 | 0.91 | POLB (0.49) | MAP3K5MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL3037228 | 0.91 | POLB (0.49) | MAP3K5MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL3033514 | 0.90 | POLB (0.54) | MAP3K5MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL3033513 | 0.90 | POLB (0.54) | MAP3K5MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL3041002 | 0.89 | STAT3 (0.51) | MAP3K5MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL3041000 | 0.89 | STAT3 (0.51) | MAP3K5MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL3036908 | 0.89 | STAT3 (0.55) | MAP3K5MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL3036909 | 0.89 | STAT3 (0.55) | MAP3K5MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL3039300 | 0.89 | POLB (0.53) | MAP3K5MEN1KMT2APOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338465-B2 | Cyclic carboxylic acid rhodanine derivatives for the treatment and prevention of tuberculosis | CORNELL RESEARCH FOUNDATION, INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-20100210577-A1 | CYCLIC CARBOXYLIC ACID RHODANINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF TUBERCULOSIS | CORNELL RESEARCH FOUNDATION, INC. | 2010-08-19 | — | — | US | disclosed |
| WO-2008005651-A2 | CYCLIC CARBOXYLIC ACID RHODANINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF TUBERCULOSIS | DECODE CHEMISTRY, INC. (US) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210577-A1 | CYCLIC CARBOXYLIC ACID RHODANINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF TUBERCULOSIS | RARG, SDHA, RARS2 | MAP3K5 3450/4885MEN1 3585/4885KMT2A 3637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.