⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8412773 | 1.00 | — | — | |
| SCHEMBL7045195 | 1.00 | — | — | |
| SCHEMBL8412779 | 0.97 | — | — | |
| SCHEMBL7049690 | 0.88 | — | — | |
| SCHEMBL16295146 | 0.88 | — | — | |
| SCHEMBL16294338 | 0.88 | — | — | |
| SCHEMBL20483089 | 0.88 | — | — | |
| SCHEMBL9284273 | 0.88 | — | — | |
| SCHEMBL823000 | 0.85 | — | — | |
| SCHEMBL17154155 | 0.78 | ALDH1A1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5912378-A | Process for preparing trimethylsilyloxy functionalized alkyllithium compounds | FMC CORPORATION (US) | 1999-06-15 | — | — | US | claimed |
| EP-0800525-A1 | PROCESS FOR PREPARING TRIMETHYLSILYLOXY FUNCTIONALIZED ALKYLLITHIUM COMPOUNDS | FMC CORPORATION (US) | 1997-10-15 | — | — | EP | claimed |
| EP-0800525-A4 | — | — | 1997-10-15 | — | — | EP | claimed |
| WO-1996003408-A1 | PROCESS FOR PREPARING TRIMETHYLSILYLOXY FUNCTIONALIZED ALKYLLITHIUM COMPOUNDS | FMC CORPORATION (US) | 1996-02-08 | — | — | WO | claimed |
| US-8357675-B2 | 17-alpha-substituted derivatives of estradiol with wound-healing activity | EUTICALS S.P.A. (IT) | 2013-01-22 | — | — | US | disclosed |
| EP-1910398-B1 | 17-ALPHA-SUBSTITUTED DERIVATIVES OF ESTRADIOL WITH WOUND-HEALING ACTIVITY | PRIME EUROP THERAPEUTICALS (IT) | 2010-11-24 | — | — | EP | disclosed |
| US-20100035796-A1 | 17-ALPHA-SUBSTITUTED DERIVATIVES OF ESTRADIOL WITH WOUND-HEALING ACTIVITY | EUTICALS S.P.A. (IT) | 2010-02-11 | — | — | US | disclosed |
| EP-1910398-A1 | 17-ALPHA-SUBSTITUTED DERIVATIVES OF ESTRADIOL WITH WOUND-HEALING ACTIVITY | Euticals S.P.A. (IT) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007014711-A1 | 17-ALPHA-SUBSTITUTED DERIVATIVES OF ESTRADIOL WITH WOUND-HEALING ACTIVITY | EUTICALS S.P.A. (IT) | 2007-02-08 | — | — | WO | disclosed |
| EP-0800525-B1 | PROCESS FOR PREPARING TRIMETHYLSILYLOXY FUNCTIONALIZED ALKYLLITHIUM COMPOUNDS | FMC CORP (US) | 2003-04-09 | — | — | EP | disclosed |
| US-5912378-A | Process for preparing trimethylsilyloxy functionalized alkyllithium compounds | FMC CORPORATION (US) | 1999-06-15 | — | — | US | disclosed |