SCHEMBL30445083

SCHEMBL30445083

COC(=O)[C@@H]1C[C@H]2CC(=O)[C@@H]1C2

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.37
SLC6A3 Q01959 3/20 0.36
SLC6A4 P31645 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2D6 P10635 1/20 0.36
TSHR P16473 1/20 0.36
MAPK1 P28482 1/20 0.36
HSD17B10 Q99714 1/20 0.36
CHRNB2 P17787 1/20 0.35
CHRNA4 P43681 1/20 0.35
CHRM2 P08172 1/20 0.35
CHRM4 P08173 1/20 0.35
CHRM3 P20309 1/20 0.35
ALDH1A1 P00352 1/20 0.34
MMP2 P08253 1/20 0.33
ANPEP P15144 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2125458 1.00 BRD4 (0.37) BRD4SLC6A3SLC6A4CYP3A4CYP1A2
SCHEMBL30444800 1.00 BRD4 (0.37) BRD4SLC6A3SLC6A4CYP3A4CYP1A2
SCHEMBL11384348 0.87 SLC6A3 (0.36) BRD4SLC6A3SLC6A4CHRM2CHRM4
SCHEMBL5162001 0.78 GABRR1 (0.36)
SCHEMBL2128128 0.78 GABRR1 (0.36)
SCHEMBL30445280 0.78 SLC6A3 (0.32) SLC6A3CYP3A4CYP1A2CYP2D6TSHR
SCHEMBL974399 0.71 CHRM2 (0.48) CYP3A4CYP1A2CYP2D6TSHRMAPK1
SCHEMBL1298159 0.71 CHRM2 (0.48) CYP3A4CYP1A2CYP2D6TSHRMAPK1
SCHEMBL974796 0.71 CHRM2 (0.48) CYP3A4CYP1A2CYP2D6TSHRMAPK1
SCHEMBL31285391 0.71 CHRM2 (0.48) CYP3A4CYP1A2CYP2D6TSHRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4405342-A2 CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-07-31 EP disclosed
WO-2023049829-A2 CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-03-30 WO disclosed