Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 18/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19577378 | 1.00 | ATF4 (0.55) | ATF4EPHX2POLB | |
| SCHEMBL21117011 | 0.92 | ATF4 (0.56) | ATF4POLB | |
| SCHEMBL19577447 | 0.92 | ATF4 (0.58) | ATF4 | |
| SCHEMBL21117016 | 0.89 | ATF4 (0.52) | ATF4 | |
| SCHEMBL24116635 | 0.87 | ATF4 (0.54) | ATF4 | |
| SCHEMBL19577377 | 0.87 | ATF4 (0.55) | ATF4 | |
| SCHEMBL19577477 | 0.86 | ATF4 (0.53) | ATF4POLB | |
| SCHEMBL22395386 | 0.86 | ATF4 (0.61) | ATF4 | |
| SCHEMBL22395301 | 0.86 | ATF4 (0.58) | ATF4POLB | |
| SCHEMBL19555690 | 0.85 | ATF4 (0.54) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3704089-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-19 | — | — | EP | disclosed |