Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25273214 | 1.00 | CDK1 (0.46) | CDK1CCNE2CCNE1CDK2NPC1 | |
| SCHEMBL25243808 | 0.81 | CDK1 (0.46) | CDK1CCNE2CCNE1CDK2NPC1 | |
| SCHEMBL30566199 | 0.81 | CDK1 (0.46) | CDK1CCNE2CCNE1CDK2NPC1 | |
| SCHEMBL25706604 | 0.77 | THRB (0.50) | CDK1CCNE2CCNE1CDK2NPC1 | |
| SCHEMBL30566240 | 0.77 | CDK1 (0.49) | CDK1CCNE2CCNE1CDK2NPC1 | |
| SCHEMBL25283284 | 0.77 | CDK1 (0.49) | CDK1CCNE2CCNE1CDK2NPC1 | |
| SCHEMBL31361255 | 0.75 | CACNA2D1 (0.43) | CDK1CCNE2CCNE1CDK2NPC1 | |
| SCHEMBL31361280 | 0.75 | CACNA2D1 (0.51) | CDK1CCNE2CCNE1CDK2THRB | |
| SCHEMBL30133420 | 0.75 | CLK4 (0.50) | CDK1CCNE2CCNE1CDK2NPC1 | |
| SCHEMBL27082684 | 0.75 | CLK4 (0.50) | CDK1CCNE2CCNE1CDK2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4440703-A1 | HETEROCYCLIC COMPOUNDS AS GCN2 AND PERK KINASE INHIBITORS | Deciphera Pharmaceuticals, LLC (US) | 2024-10-09 | — | — | EP | disclosed |
| CN-118715223-A | Heterocyclic compounds as GCN2 and PERK kinase inhibitors | 德西费拉制药有限责任公司 | 2024-09-27 | — | — | CN | disclosed |
| WO-2023102228-A1 | HETEROCYCLIC COMPOPUNDS AS GCN2 AND PERK KINASE INHIBITORS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2023-06-08 | — | — | WO | disclosed |