Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.38 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL11298779 | 0.89 | CA1 (0.31) | CA4FAHD1CA1 | |
| SCHEMBL9639951 | 0.89 | CA4 (0.46) | CA4FAHD1CA1MEN1LDHA | |
| SCHEMBL22782 | 0.89 | — | — | |
| SCHEMBL9082732 | 0.86 | CA4 (0.38) | CA4FAHD1CA1MEN1LDHA | |
| SCHEMBL4300381 | 0.86 | CA4 (0.38) | CA4FAHD1CA1MEN1LDHA | |
| SCHEMBL17595204 | 0.86 | CA4 (0.38) | CA4FAHD1CA1MEN1LDHA | |
| SCHEMBL2024372 | 0.86 | CA4 (0.38) | CA4FAHD1CA1MEN1LDHA | |
| SCHEMBL8717562 | 0.86 | CA4 (0.38) | CA4FAHD1CA1MEN1LDHA | |
| SCHEMBL11161642 | 0.86 | CA4 (0.38) | CA4FAHD1CA1MEN1LDHA | |
| SCHEMBL8713969 | 0.86 | CA4 (0.38) | CA4FAHD1CA1MEN1LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7125497-B1 | Reactive formulations for a neutralization of toxic industrial chemicals | SANDIA CORPORATION (US) | 2006-10-24 | — | — | US | claimed |
| US-7750199-B1 | Kit systems for granulated decontamination formulations | SANDIA CORPORATION (US) | 2010-07-06 | — | — | US | disclosed |
| US-20070249509-A1 | GRANULATED DECONTAMINATION FORMULATIONS | NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC | 2007-10-25 | — | — | US | disclosed |
| US-7276468-B1 | Granulated decontamination formulations | SANDIA CORPORATION (US) | 2007-10-02 | — | — | US | disclosed |
| US-7271137-B2 | Decontamination formulations for disinfection and sterilization | SANDIA CORPORATION (US) | 2007-09-18 | — | — | US | disclosed |
| US-7125497-B1 | Reactive formulations for a neutralization of toxic industrial chemicals | SANDIA CORPORATION (US) | 2006-10-24 | — | — | US | disclosed |
| WO-2005089100-A2 | DECONTAMINATION FORMULATIONS FOR DISINFECTION AND STERILIZATION | SANDIA CORPORATION (US) | 2005-09-29 | — | — | WO | disclosed |
| WO-2005057588-A2 | GRANULATED DECONTAMINATION FORMULATIONS | SANDIA CORPORATION (US) | 2005-06-23 | — | — | WO | disclosed |
| US-20050109981-A1 | Decontamination formulations for disinfection and sterilization | NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC | 2005-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050109981-A1 | Decontamination formulations for disinfection and sterilization | CAT, PRKDC, PRKACG | CA4 1020/4885FAHD1 1348/4885CA1 1545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.